Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that causes joint destruction and functional disability. In this study we take 200 normal individual and 200 rheumatoid arthritis patient. For the biochemical parameter to be analyzed, blood samples were drawn from the anticubital vein avoiding venostasis. In all subjects a blood sample was collected after an overnight fast.The study found a significant decreased Hb% and significantly lower levels of serum iron &TIBC in RA patients as compared to control. The result suggested that routine dietary supplementation with multivitamins and a trace element is appropriate in rheumatoid arthritis patients.