A diagnostic procedure is needed to rule out hyperplasia or cancer if the patient is symptomatic or has abnormal cytology. Diagnosis of endometrial hyperplasia is usually made by sampling the endometrial cavity with an endometrial biopsy in the office or dilation and curettage in the operating room. Tissue sampling should be performed in women with risk factors who present with symptoms of abnormal vaginal bleeding or discharge. This includes women older than 35 years with abnormal bleeding, women younger than 35 years with bleeding and risk factors, women with persistent bleeding, and women with unopposed estrogen replacement therapy. 100 women in the premenopausal and postmenopausal age with abnormal uterine bleeding were subjected to transvaginal ultrasound and endometrial sampling. Obesity was an independent and significant risk factor for endometrial hyperplasia and carcinoma. The risk of endometrial hyperplasia increased in premenopausal women with anovulatory cycles which was statistically significant.Prior anovulatory cycles among postmenopausal women was a significant risk factor.