Background: Ulcerative colitis is considered to be common in western developed countries compared to Asians. However, recent studies show increasing number of cases in Asia, with various intestinal and extraintestinal manifestations with typical histology. This study was designed to know the clinical profile of the disease which helps in better understanding of the disease ,its extraintestinal manifestations and it’s histology. Objectives: To study the clinical and lab profile of patients with ulcerative colitis which includes most common manifestations, extra–intestinal manifestations of ulcerative colitis in tertiary care hospital. Mangaluru. Materials & Methods: Biopsy proven ulcerative colitis cases from 1 st january 2016 to 31st december 2017 in Father Muller medical college, Mangalore, satisfying the selection criteria were included. Clinical features, Endoscopy findings, Lab findings and histology were obtained from MRD files. Statistical analysis was done using SPSS 23. Results: Among the included patients, 63% were males. Bloody Diarrhea, mucus discharge and abdominal cramp were the most common symptoms. Joint involvement in the form of arthritis and liver involvement in the form of fatty liver were the most common extraintestinal manifestations. Patients were found to have high ESR(70%), hypoalbuminemia(85%) and anemia(50%) . Typical histology findings were presence of crypt abscess, cryptitis, infiltration of lamina propria with neutrophils, lymphocytes and eosinophils and mucosal depletion. Conclusion: Ulcerative Colitis is more prevalent in males than females, and common in elderly, with bloody diarrher mucus discharge and tenesmus being most commonest intestinal manifestation. Extra–intestinal manifestations mainly related to joins,hepatic and skin involvement.Typical histological pattern includes Lamina propria infiltrated with Neutrophils , Lymphocytes; Crypt abscess ,Cryptitis, Crypt branching. Ulcerative colitis an important premalignant condition , colonoscopy and evaluation at regular interval is needed to take precaution against colorectal cancer.