Postmenopausal women are more prone for cardiovascular disease due to decreased or complete absence of endogenous estrogen hormone. Cardiovascular disease (CVD) is the leading global cause of death, in that 49% of them are female population. The risk of CVD increases sharply after menopause and the exact underlying mechanism for association of post menopause with cardiovascular disease needs to be evaluated. So, we analyzed serum hsCRP, an inflammatory marker and lipid peroxidation levels in 55 Post–menopausal women in the age group of 45 to 55 years (obese: n=30 and non–obese: n=25) with no history of cardiac and other chronic disorders. Ethical clearance and written consent were obtained. hs–CRP was assayed by ELISA method and lipid peroxidation as thiobarbituric acid reactive substances (TBARS) was estimated using spectrophotometer. High sensitivity C – reactive protein (hs–CRP) and TBARS were found to be significantly elevated in obese post–menopausal women than in non– obese (p<0.05). There was significant positive correlation between hs–CRP and TBARS (p<0.01) in post–menopausal women. It is concluded that elevated oxidative stress and inflammation could increase the risk for CVD in obese postmenopausal women.