Background: Leprosy is a chronic infectious disease that caused by Mycobacterium leprae. It’s still endemic especially in underdeveloped or developing countries. The prevalence has decreased since the introduction of MDT in the beginning of the 1980s. Purpose: to determine the prevalence of leprosy in Primary Health Care Outpatient Karang Taliwang Mataram January–December 2018. Methods: A descriptive retrospective study which data gathered from medical record. Results: The leprosy number is 3 patients. Prevalence of leprosy in Primary Health Care Outpatient Karang Taliwang Mataram is 0.74 per 10.000 population. The predominant age group were adulthood >15 year old (100%) with all patient is male (100%). The most tribe is Balinese (66.67 %), and the most leprosy type of patients were Multibacillary (100%). Conclusion: The prevalence of leprosy in Primary Health Care Karang Taliwang Mataram is 0.74 per 10.000 population. Most patient is at adulthood, male, Balinese tribe, and Multi Bacillary type.