Hysterectomy for fibroids is one of the commonest gynaecological surgeries in India. To reduce the morbidity and mortality associated with the surgery a number of medical treatments have been tried. Mifepristone is one of them and is being used in the recent decade as a more or less effective option in the treatment of myoma. This study was undertaken to evaluate the efficacy and safety of low dose mifepristone in medical management of uterine myomas. Women with symptomatic myomas or myoma of more than 5cm were included in this study. They were given oral mifepristone 25mg per day for 3 months. Patients were followed at 1, 3 and 6 months. The prospective clinical trial was conducted from august 2006 to august 2018 at my clinic. It was found that blood loss reduced significantly in 3 months therapy and the effect started from the first cycle onwards. Amenorrhoea developed in 90% – 95% patients which reverted later.