Many of us have heard or read about artificial sweeteners affecting the thyroid.That was a stunning example reported at first time in American Association of Clinical Endocrinologists (AACE) 22nd Annual Scientific & Clinical Congress. Hypothyroidism is posing a major challenge both in developing as well as developed countries.The use of sugar substitutes (artificial sweeteners or non–nutritive sweeteners) has increased dramatically in the past few decades. They have been used as a substitute for sucrose (table sugar) in various diet–related disorders. Their excessive use has been linked to hyperphagia and obesity–related disorders. Hashimoto’s thyroiditis (chronic autoimmune thyroiditis) is a disease that involves the immune–mediated destruction of the thyroid gland, gradually leading to its failure. Animal studies report that artificial sweeteners affect the immune system. Moreover, animal studies show that sucralose diminishes the thyroid axis activity. Ayurveda from its existence into the modern world is facing a major challenge.Endocrine disorders are difficult to understand in Ayurveda.Though certain disorders like Diabetes mellitus are well described in various Ayurvedic texts but as far as diseases of thyroid gland are concerned they are not well understood.In Ayurveda , we correlates the disorders caused by thyroid gland as Galganda, Gandmaala etc but the concept of hormone overproduction or under secretion is somewhere missing.Hence , here is an attempt to get the understanding of disease autoimmune Hypothyroidism induced by sugar substitute through various ayurvedic principles.