Introduction: Thrombocytopenia is characterized as platelet less than 1,50,000/μL. This is because of diminished creation, expanded obliteration, and expanded sequestration in spleen. Hence, we planned the present study to analyze the clinical profile of febrile thrombocytopenia. Methods: The present study included assessment of clinical profile of febrile thrombocytopenia. A total of 200 subjects were included in the present study. At the time of diagnosis, complete detailed history of all the patients was taken along with thorough clinical examination. Etiologic and clinical data of all the patients was recorded and compiled. Results: Out of total 200 cases included in the present study, fifty–two cases were due to viral fever while fifty–seven cases were due to malaria. Jaundice and cough was present in 52 and 58 cases respectively. In fifty five percent of the cases, platelet count was between 50000 to 10000 per cubic mm. Conclusions: Infectious diseases accounts for most of the cases of febrile thrombocytopenia.