Background According to Ayurveda kshetra means the place where beej implants and from modern point of view fertilized ovum implants itself in the endometrium of the uterus. So we can correlate khsetra with endometrium. Nowadays changing food habits, lack of exercise, sedentary work, loss of emotional support, competition in every field, incresed stress all these factors of modern lifestyle influences on physical and mental health of human beings. In women, normal and regular menstrual cycles are indication of good reproductive behaviour and menstrual cycle is influenced by hypothalamo–pituitary–ovarian axis. Incresed stress, incresed BMI index, affects hypothalamo–pituitary–ovarian axis, which inturn disturbes endometrial behaviour. Materials and Methods In this paper various textbooks and journals are studied . Conclusion We can conclude that modern lifestyle affects endometrium’s (kshetra) receptivity which may be responsible for implantation failure.