Aim: This study aims to find out association between expressions of a panel of two immunohistochemistry (IHC) markers including Cyclin D1 & Ki 67 in cases of head & neck squamous cell carcinoma (HNSCC) in a pan–India cohort. Materials and methods: A total of 103 cases of HNSCC presenting to our centre between Jan 2016–Dec 2018 with available clinical details were included in the study. Cases of in–situ carcinoma were excluded from the study. All 103 cases were subjected to IHC with Cyclin D1 and Ki 67 following standard protocol by manual method. Cases were then interpreted as positive, negative or indeterminate for the above antibodies. Results: Ki 67 nuclear proliferation index as a percentage value was found to be associated with higher grade HNSCC and more aggressive clinical behavior of the tumor. Whereas, Cyclin D1 did not show significant association with important tumor attributes. Conclusion: Ki 67 mitotic index is significantly associated high grade HNSCC. Though, similar findings have been found in many other studies across the world, more such studies from India need to be done to make this finding clinically relevant.