Introduction: Diabetic patients being on rise, a significant amount of patients now need insulin to manage their blood sugars and hence aim of this study was to study the barriers in starting insulin to patients with diabetes. Methods: This hospital based descriptive observational study was conducted on 104 patients of diabetes in the department of general medicine in a tertiary hospital in central India. Participants were randomly selected, and then they completed the insulin noncompliance questionnaire (20 questions). Results: Out of the total 292 patients studied, the most common reason for insulin refusal was fear of needles (64.7%) followed by belief in alternate medicine for insulin control (20%), followed by requiring someone else to administer the injection (19.2%), cost (18.7%). Conclusion: In India due to widespread propaganda of alternate medicine, the trust of patients in modern medicine has decreased. Therefore, targetted educational interventions can help minimize these problems and improve patients’ outcomes.