Introduction: Chronic kidney disease is increasingly recognized as a major public health burden and the leading cause of morbidity and mortality globally. The prevalence of CKD is as much as 10–15 percent worldwide but in India the exact figure is not known due to the lack of proper registry data and few population–based studies done. Kidney failure resulting from CKD is prevented via dialysis or transplantation. Method: Quantitative Research Approach was used. Quasi– Experimental Time Series Design with two post–test observations over a gap of one week was employed. The Conceptual framework used was based on Orem’s Self–Care Theory. The study was conducted at the Dialysis Unit of ILBS on a total of 60 patients undergoing MHD, who were then randomly allocated into Experiment and Comparison groups. Data was collected using standardized and structured questionnaires after establishing the validity and reliability. Statistical analysis was done on SPSS Version 22.0, using the descriptive and inferential statistics. Results showed that almost half (E– 46.7%, C– 60%) of the patients were 50–65yrs of age and males (E– 73.3%, C– 66.7%). Majority of the patients in both the groups had average level of knowledge at baseline. Study groups were found homogenous in terms of baseline Knowledge, Practice and Self–Efficacy scores. The mean difference in the Knowledge scores only was found highly significant between the groups both over time (F= 86.09, p= 0.001) and across the group with time (F= 73.41, p= 0.001). Spearman’s correlation between Change in Knowledge and Practice of patients in the Experiment group was also found highly significant (ρ= 0.499, p= 0.005). Conclusion: The e–SIM was found highly effective in improving and retaining Knowledge of Self– Management in patients undergoing MHD.