Background: 1984 Gas tragedy was a result of the release of Methyl isocyanate from a pesticide plant in Bhopal accounting for death of millions. The health effects were recorded from the survivors ranging from ocular, respiratory, reproductive system, psychological to genetic damage. Chromosomal aberrations have also been reported exposed to the gas and experimental studies exposed to methyl isocyanate revealed changes in developing foetus including reduction in length of mandible. However, cross generational study of the effects of the exposure to methyl isocyanate have been far and few. Aim: This study was an attempt to study the prevalence of craniofacial deformities in the first–generation survivors of Bhopal gas tragedy and to evaluate the possible role of methyl isocyanate in the causation of cross–generational craniofacial anomalies. Material & Methods: The present study was based on a survey of the tragedy survivors comprising of 500 subjects of the first– or second–generation tragedy survivors and 200 subjects of non–exposed areas taken as the control group. Interpretation and conclusion: The results obtained showed the disastrous chemical nature of MIC, its association with Orofacial clefts, the prevalence of mental retardation in relation to exposure of MIC and a higher male predilection of these anomalies.