While treating a patient with left sided chest discomfort associated with anxiety, palpitation, dyspnea or diaphoresis, our vision sometimes narrows down to primarily the heart, lungs and esophagus. We report 3 cases where patient reported with symptoms mimicking acute coronary syndrome but detailed evaluation and investigations ruled out cardiac abnormalities, rather hypothyroidism was attributed to for the symptoms.In the field of medical science where rarities are no exception, a physician should try to exclude hypothyroidism in cases where he finds the conventional evaluations for a case of chest pain inconclusive.