The management of a large unilateral staghorn calculus especially associated with recurrent urinary tract infections is difficult to treat surgically hence laparoscopic approach can be used to manage it effectively in a single sitting. the present study aims at studying the role of laparoscopic pyelolithotomy in the management of unilateral staghorn renal stones with recurrent infections. Methodology: It was hospital based retrospective observational study carried out in the department of general surgery in a tertiary hospital in central India with certain inclusion and exclusion criteria and a total of 30 patients were studied from January 2018 to December 2018. Observations and results: A total of 30 patients were selected of which 18 were males and 12 were females. The present study aims at studying the role of laparoscopic pyelolithotomy in the management of unilateral staghorn renal stones with recurrent infections. The mean hemoglobin drop at day 3 after the operation was 0.4±0.88 g/dl and there was no blood transfusion required in any patient.