The thalassemia syndrome is the commonest genetic blood disorder, clinically divided into three broad groups: thalassemia major, intermedia and minor. Now–a–days, with adequate transfusion and chelation therapy, survival is prolonged into teens and early 20s and few successful pregnancies are possible. But, only a few studies are available on the effects of thalassemia in pregnancy. This study was conducted in the Department of G&O, NRS Medical College, Kolkata with an objective to determine the frequencies of different types of thalassemia in pregnancy, its effects on pregnancy, find out measures to reduce the complications attributable to it during pregnancy, and to improve maternal and perinatal outcome.