OBJECTIVES: The objectives of the study is to assess peripheral inflammatory indices–neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), mean platelet volume (MPV) in bipolar affective disorder (BPAD) and healthy controls (HCs) SUMMARY : Consecutive drug–naive patients or not on any concomitant medicine for last 6 months with 72 Bipolar affective disorder (52 with manic episode and 20with depressive episode) and 91 Healthy Controls were studied. Neutrophils, lymphocytes, monocytes, platelets, NLR, PLR and MPV were measured and unpaired student’s t– test used for statistical analysis. The BPAD patients had statistically significant elevated neutrophils, monocytes, platelets, NLR, PLR, MPV and lower lymphocytes compared to the Healthy Control group. BPAD is associated with higher level of inflammatory indices compared to Controls.