The study was designed to evaluate the efficacy of 0.3mg buprenorphine hydrochloride added 2% lignocaine hydrochloride with adrenaline 1:200000 in providing postoperative analgesia after minor oral surgery. 60 adult patients who were scheduled to undergo surgical removal of impacted mandibular third molar were enrolled in this study. Patients were randomly assigned into one of the two groups based on whether they received 0.3mg buprenorphine hydrochloride added 2 % lignocaine hydrochloride with adrenaline 1:200000 (Group A) or (Group B) 2 % lignocaine hydrochloride with adrenaline 1:200000 alone. Visual analog scale method was used for evaluation of the postoperative analgesia. Addition of small amounts of 0.3mg buprenorphine hydrochloride (0.25ml) to (9.75ml) 2% lignocaine hydrochloride with adrenaline 1:200000 for surgical removal of impacted mandibular third molar results in significant improvement in postoperative analgesia up to 72 h and markedly reduces the need for excessive analgesic intake. Thus reducing the adverse effects associated with excessive use of NSAIDs.