Objective : Assessment of maternal serum levels of vascular endothelial growth factor and placental growth factor in threatened abortion cases with and without sub–chorionic hematoma. Materials and Methods: 3 ml of peripheral blood sample was collected from each case. The plasma was separated and quantification of VEGF and PlGF was done using ELISA kits. Results: The VEGF levels were 24.90 ± 16.16 pg/ml if sub–chorionic hematoma was present and the levels were 31.29 ± 9.59 pg/ml in the absence of hematoma. Hence the VEGF level was significantly decreased in the presence of sub–chorionic hematoma. Whereas the PlGF value was 281.76 ± 57.95 pg/ml in the presence of sub–chorionic hematoma and the value was 257.46 ± 71.01 pg/ml in the absence of hematoma with the p–value 0.29. Conclusion: Keywords: Threatened abortion, VEGF, PlGF, SCH