INTRODUCTION: To study the clinical profile, effected heart valves and the organisms involved and prognostic factors in patients undergoing surgery for infective endocarditis. MATERIALS AND METHODS: All patients who were admitted and operated for infective endocarditis from 2011 through 2017 in single unit of NIMS hospital were included in the study. The study protocol was approved by the Hospital Ethics committee. RESULTS: A total of 30 patients with infective endocarditis were operated between 2011through 2017. 22 males and 8 females,mean age was 36.7.Out of 30 patients 29(96%) of the patients had native valve endocarditis (NVE) and only 1 patient had prosthetic valve endocarditis (PVE).The Mitral valve was involve in 12 (40%), Aortic valve 10 (33%) and both valves were effected in 6 patients. The most common indications for surgery were refractory heart failure and persistent infection, 9 and 5 respectively. Heart failure and sepsis were the major post–operative complications. Elevated liver aminotransferases had significant association with in–hospital mortality (p value AST–0.024; ALT–0.004). There were 9 deaths during study period. CONCLUSIONS: Surgery for infective endocarditis still carries a high mortality rate. Elevated liver aminotransferases are helpful in predicting mortality rates.