IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-11-23071 Original Research Paper URIC ACID : AN INFLAMATORY MARKER IN PREECLAMPSIA ? Priyank Udagani Dr. H.L.Vishwanath Dr. November 2019 8 11 01 02 ABSTRACT

The pregnancy is the state of carrying a developing embryo or fetus within female body1. Preeclampsia affects 3–5% of pregnancies. Placental ischemia and inflammation occur due to impaired trophoblastic invasion in uterine spiral artery. Preeclampsia is an idiopathic multisystem disorder that typically starts after the 20th week of pregnancy; high blood pressure is a main contributing factor. Ten million women develop preeclampsia each year around the world. In hypertensive pregnancy however, there is incomplete trophoblastic invasion upto decidual vessels, but not upto myometrial vessels. Because of this, myometrial spiral arteriolar lumen remains narrow which impairs blood flow to produce placental hypoxia. Aim and Objectives: Aim of the study is to study wheather Uric Acid is an inflammatory marker of Preclampsia. Results : 30 women in preeclamptic compared with 30 normal pregnant with similar age and period of gestation . The mean SBP of the cases and controls are 157.7 mm of Hg and 113.6 mm of Hg with significant p value < 0.0001. The mean DBPin cases and controls is 101.4 mm of Hg and 77.47 mm og Hg with significant p< 0.0001. The mean serum uric acid in cases and controls are 6.41 mg/dl and 4.33 mg/dl respectively With p < 0.0001.