Introduction and objectives: Breast cancer one of the common cancer in females worldwide. Incidence of breast cancer is rising in India as in all over world. This study was aimed at assessment of QOL after Modified radical mastectomy(MRM) in cancer survivors. Material and methods: One year after MRM, QOL assessed in 100 breast cancer survivors using WHOQOL–BREF questionnaire instrument at GND hospital, Amritsar, Punjab. Results: The mean age of the breast cancer survivors was 55.72 (SD 11.86). Mean(SD) of Overall quality of life was 7.3 (0.732), of Physical domain was 72.25(5.30), Psychological domain 71.3(6.72), Social domain scores67.67(6.19) and of environmental domain was 69.12(2.95) respectively. Highest domain was of physical, followed by psychological and environmental domain. Social domain represented with least scores. Younger patients with <50 years of age with better education and occupation and having high socioeconomic class have better general QOL perception. Younger age groups, unmarried, educated and high socio–economical classes have better perception of their physical and environmental factors. Social and psychosocial scores are better with increasing age, married life, higher education and good monthly income. Conclusion: QOL is affected in most of breast cancer survivors as all the domains of life get affected after diagnosis and treatment of cancer. Most of the patients appreciated optimum level of satisfaction after MRM. There is a definite role of education, counselling and support as well as need of strengthening of health care system to conquer these potential areas in life of any cancer survivor.