INTRODUCTION: Diabetes mellitus (DM) is a non–communicable disease with increasing prevalence worldwide.Poorly controlled diabetes leads to various complications such as nephropathy, retinopathy, neuropathy and oxidative stress causing oxidative damage to tissues and cells.The concentration of HbA1c depends on the concentration of glucose in the plasma and the duration of hyperglycemia and is an index of diabetic control for a period over past 12 weeks.Anemia, leucocytosis and thrombocytosis are common hematological finding in diabetic patients early evaluation of this parameter prevent complications. METHOD: The case–control study was carried out for 3 months duration at L.G.Hospital, Ahmdabad. All uncomplicated type –2 DM patients visited to OPD or indoor were included in study. Hematological parameter of these patients compared with non–diabetics indivisuals. RESULT: Statistically significant correlations observed in anemia(p<0.0001) and thrombocytosis(p= 0.004) between two groups. Mean WBCs (8382/cumm vs 7917/cumm)count higher in diabetics than non–diabetics group but was not statistically significant(p=0.29). CONCLUSION: Hematological profile in Diabetes patients is deranged and diabetics are more prone for anemia and thrombocytosis. Routine and regular screening for hematological profile initiate early prevention strategies and reduce the morbidity related to it. Hence hematological parameter should be done along with glucose profile for early assessment of disease progression and to prevent morbidity.