Background: The term “autopsy” derives from the Greek word “autopsia” meaning “to see for oneself” i.e. making a personal inspection. Non–traumatic (natural) brain lesions could be due to increased intracranial pressure, cerebrovascular diseases, metabolic disorders, tumors of the central nervous system (CNS), neurodegenerative diseases, infections of the CNS and myelin diseases.(1) This study was carried out to see the spectrum of brain lesions. Methods: This was a prospective study done in a tertiary care teaching hospital for a period of 2 years. Total of 235 patients were included in the study. Histopathological examination of the specimen was done and the various histopathological patterns identified and classified. Results: The age of patients ranged from 11–80 years. 24.25 % were in the age group 21–30 years . The most frequent mode of death was traumatic affecting 71.06 % of patients. Intracranial SOLs were most commonly noted in age group 41–50 years in 4 cases (33.3%) and Anaplastic astrocytoma was the most common intracranial lesion. Conclusions: In India, postmortem examination is being done to confirm the clinical diagnosis and provide cause of death in most of the cases.