Liver transplantation, a life saving surgical procedure for patients with end–stage liver disease and acute liver failure, initiates a cascade of patho–physiological responses, potentially causing post–operative pulmonary complications and functional dependency. Early post–operative physiotherapy aims to avoid those complications and also to improve the functional status of the patient. Therefore, this case study describe the course and effect of physiotherapeutic measures for a patient of 54 years who undergone living donor liver transplantation in a tertiary care hospital. Understanding the effectiveness of physiotherapeutic treatment in early post–operative transplantation surgery will help the physiotherapists to gain fundamental knowledge, which will help them to select the appropriate respiratory and functional exercise for patient with liver transplantation