BACKGROUND AND OBJECTIVES: According to the WHO, India is home to 12% of the world‘s smokers. More than 1 million die each year due to tobacco in India. Cigarette smoking is one of the most extensively used potentially hazardous social habits throughout the world. MATERIAL AND METHOD: The study was conducted on 150 normal asymptomatic healthy males. Out of which 75 were controls and 75 were cigarette smokers with age–group between 17–35 years. The association of cigarette smoking and raised blood cholesterol levels was studied. RESULTS: The study showed, cigarette had raised concentration of serum total cholesterol, triglycerides, LDL–cholesterol, VLDL–cholesterol and had reduced levels of HDL cholesterol. CONCLUSION: We observed a dose response relationship between the number of cigarettes smoked and cardiovascular morbidity and mortality.