Back ground– Inflammation plays a major role in many diseases such as osteoarthritis. Lansoprazole,a Proton pump inhibitor might have anti–inflammatory effect due to its chemical structure. Objective–To evaluate the anti inflammatory effect of Lansoprazole in adult male albino Rats. Methodology–The anti–inflammatory effect of graded doses of T.Lansoprazole (5 mg/kg ,10 mg/kg) was evaluated by 1% Carrageenan induced paw edema and measuring it using Plethysmometer.It was compared with the standard drug Aspirin. The values obtained were expressed as mean ± S.D. and percentage inhibition calculated. Statistical analysis of difference between groups was carried out using one– way Analysis of variance(ANOVA).Probability (P) value of < 0.05 was taken as the level of statistical significance. Result – T.Lansoprazole at both doses of 5 mg and 10 mg produced significant inhibition of paw edema at a P–value of < 0.01. Conclusion– T.Lansoprazole had anti inflammatory property both at 5mg/kg and 10 mg/kg dose and it was comparable to that of T.Aspirin 300mg/kg .