Introduction: The study objective was to create awareness and evaluate the effect of structured teaching programme on knowledge and attitude on organ donation among the engineering students. Material and Methods: It was one group pre–test and post–test design. The study was conducted among 367 engineering students in Puducherry. The tool used to measure awareness by 24 items self–administered Questionnaire and the attitude on organ donation was measured by five–point Likert attitude scale. Results: After the intervention among 367 participants 267 (72.8%) were having moderately adequate knowledge and 238(64.9%) having moderately favorable attitude on organ donation. It is inferred that there was improvement in the level of knowledge and attitude after the educational intervention which was statistically significant (p<0.001). Conclusion: The engineering students has gained knowledge and change desirable attitude on organ donation after the educational intervention.