Objectives: To analyze the available literature to assess the diagnostic potential of salivary miRNAs in the early detection of OSCC. Materials and Methods: A systematic review was carried out in the PubMed/ Medline electronic databases with keywords “Salivary microRNAs and Oral Cancer” and articles fulfilling the objective of the study were included. Results: The searches revealed 968 articles out of which 11 articles conducted on isolation of miRNAs from saliva of OSCC patients were included in this systematic review. Evidence from various studies suggests that miRNAs are significantly de–regulated in saliva of OSCC patients compared to healthy controls. Most of miRNAs were under expressed (miRNA125a, miRNA–136, miR–137 and miRNA–147, miR–193a miR–200, miRNA200a, miR–205 miRNA–1250, miRNA–148a, miRNA–632, miRNA–646, miRNA668, miRNA–877, miRNA–503, miRNA–220a, miRNA–323–5p), 2 miRNAs were over expressed (miRNA–24, miRNA–27b), MiRNA–27b levels were significantly higher in OSCC patients. Conclusion: OSCC is associated with a range dysregulated miRNA expression patterns particularly under expression which indicates tumor expansion and progression. miRNAs in human saliva may be used as potential biomarkers for early diagnosis of OSCC as well as postoperative follow–up. Saliva based diagnostics offers a promising future as it can be used as a non–invasive and rapid diagnostic tool for detection of OSCC.