Background: Laparoscopic cholecystectomy is gold standard surgery for symptomatic gall stone disease which is the commonest disease needs surgical management. Symptomatology of the patients having upper GI pathologies can mimick the symptomatic gall stone disease and vice versa. Though biliary colic is specific for gallstones. Patients presenting with other gastrointestinal symptoms can also have gall stones. In this study UGI endoscopy was done for all patients with symptomatic and investigation proved gall stone disease to rule out other pathological causes of gastrointestinal tract and prevent post cholecystectomy syndrome. Methods: Patients with Ultrasonography suggestive of single or multiple gall stones were included. Upper GI Scopy was done prior to laparoscopic cholecystectomy as per inclusion and exclusion criteria. All patients above 18years, with ultrasonographically proven diagnosis of cholelithiasis Results: In present study, 153 patients were included. Pain in abdomen was present in 88.2% of patients. Nausea/vomiting was second most common symptom and seen in 60.78%. It is also seen that OGD findings were abnormal in 108 patients (i.e.70.58%) and OGD findings were normal in 45 patients. The patients with abnormal ODG findings were subjected to pre op treatment of the respective GI pathology. Hence after Lap Cholecystectomy , post operatively patients were highly satisfied and relieved of their symptoms Conclusions: Cholecystectomy can be curative only whose symptoms are due to gallstones, and not due to other upper GI pathologies. Approach of performing OGD as a routine investigation prior to cholecystectomy, will decrease persistence of symptoms and prevent post–cholecystectomy syndrome.