Care of the newborn diagnosed with a malignancy is a challenge for the neonatal intensive–care unit nurses. Malignancies found in infants differ from those found in ‘older children. Nursing care of the neonate suspected or diagnosed with a malignancy includes problem identification and standard practices as well as interventions unique to the patient with cancer. This article reviews the incidence, diagnosis, treatment, and nursing management of neuroblastoma diagnosed in neonates.