Introduction : The Syntax score is a comprehensive, angiographic tool in grading the complexity of coronary artery disease (CAD).Materials And Method: Hospital based observational study was conducted in patients with coronary artery disease presenting to the KING GEORGE HOSPITAL, Visakhapatnam during study period between August 2017 to July 2018.Results : SYNTAX scores of patients with diabetes mellitus 30.85 ± 14.93 vs 15.91 ± 12.14 in non–diabetics , hypertensives 24.32 ±15.20 vs 16.03 ± 13.13 in non–hypertensives , smokers 27 ± 17.08 vs 17.86 ±12.59 in non–smokers . The mean SYNTAX scores Ankle Brachial Index in normal i.e, 16.31 ± 13.49 vs 28.97 ±13.96 in abnormal . Conclusion : The present study concludes that Diabetes, hypertension, smoking, Ankle brachial index are having greater association with of severity of atherosclerosis by SYNTAX score except for Waist Hip ratio