Isolated pancreatic tuberculosis (TB) remains a rarity despite the high incidence of tuberculosis in many of the African and Asian countries. Presentation as discrete pancreatic mass often masquerades as pancreatic neoplasm and diagnosis may require histology. We report here a case of isolated pancreatic TB with pancreatic head mass mimicking neoplasm. The possibility of TB should be considered in the list of differential diagnoses of pancreatic mass and an endoscopic, ultrasound–guided biopsy might help to clinch the diagnosis of this potentially curable disease.