Labour is a process leading to chilbirth in which.Cervical dialation,is an important factor ,which can sometimes be improper despite of having good uterine contractions leading to prolonged labour 1.Hence considering various complications arising from prolonged labor,the use and efficacy of Drotaverine 2 and Epidosin is being studied. A comparative study of 100 pregnant women with singleton pregnancy without complications ,with intact memberanes and cervical dialation of 3 cms and effacement of 50 % was done at Mata Chanan Devi hospital ,New Delhi in the year 2015–2016 ,which were divided into two groups of 50 pateints each.One group of pateints wer given Inj Drotavarine 40 mg I.M. with repeat dosage at 2hr interval and the other group were administered Inj Epidosin 8 mg I.M. with repeat dosage in 30 minutes.Maximum of 3 doses were administered in both the groups. The study shows that Drotavarine was more effective and safer in accelerating labour 3 with fewer side effects.