Adequate mydriasis is crucial for cataract surgery. To perform a safe operation the pupil needs not only to be dilated preoperatively but preferably needs to remain dilated throughout the procedure. Intraocular Adrenaline is routinely being used as a mydriatic in irrigating eye solutions during phacoemulsification and intraocular lens implantation. This study aimed at assessing the systemic side effects of intraocular adrenaline. Material and Method: This study was conducted at a tertiary care centre of central India. Sixty cataract patients both male and females aged between 50–70 years were voluntarily enrolled who underwent phacoemulsification and intraocular lens implantation surgery. All patients belonged to ASA physical status 1and 2. Thirty patients were hypertensive on treatment, well controlled. The other thirty were normotensive. Intraoperatively vital parameters like Heart rate, Blood pressure and Respiratory rate were monitored by standard multipara monitors and Pre & Post operative blood sugar levels were analysed biochemically by Hexokinase method. Data was analyzed using the IBM SPSS for Windows software package. T–tests were used to determine statistically significant pairwise differences. Conclusion: There were no significant differences between the two groups. The rise in vital parameters which subsided with progress of surgery was most likely neurogenic response to surgery.