Introduction: Prostate gland is crucial source of morbidity and mortality in elderly males. The spectrum of lesions includes Inflammation, BPH and Malignancy. Histomorphological diagnosis and its grading in malignancy plays cardinal role in management of prostatic lesions. Current study aims at analyzing histomorphological spectrum of lesions in prostate. Materials and Methods: Current study is done in Department Of Pathology of Tertiary Hospital from May 2018– 19. Total 98 samples were received during this period. The received biopsy was grossed, processed and Haematoxylin and Eosin slides were prepared for reporting. Results: Total 98 cases with ageranged from 30 to 82 years.74 cases were non–neoplastic and 24 neoplastic. Conclusion: As per current study, 51 – 80 years is the commonly affected age group. BPH is the most common lesion. Of which BPH with chronic inflammation is most common non–neoplastic lesion .All malignant cases are of Adenocarcinoma.