Background : Chronic kidney disease(CKD) disrupts the homeostasis of the body by ill effects on various physiologic systems, endocrine system being one of them . There have been many studies about thyroid dysfunction in patients with acute systemic illness and in CKD patients not on maintenance hemodialysis. The data regarding prevalence of thyroid dysfunction in persons with chronic kidney disease (CKD) requiring chronic dialysis is sparse. Objective:The present study was done to assess the prevalence and type of subclinical thyroid dysfunction in patients of chronic kidney disease(CKD) on maintainance hemodialysis Study methodology: Cross–sectional data from 100 adult patients who were registered in the hemodialysis unit of Guru Gobindsingh Civil Hospital, Jamnagar, Gujarat, India, was analyzed with Multivariable logistic regression analysis.The data consisted of estimated Glomerular filtration rate (eGFR), calculated by the abbreviated Modification of Diet in Renal Disease(MDRD) equation and serum TSH, serum free T3 and serum free T4. Results: Statistically nonsignificant negative correlation was found between estimated GFR and serum TSH, serum free T3, serum free T4 (Pearson’s correlation r= – 0.178, – 0.052 and –0.110 respectively). Conclusion: In our study we found that although subclinical thyroid dysfunction, more of subclinical hypothyroidism is detected in patients of chronic kidney disease on maintainance hemodialysis, it is not statistically significant.