Background: The present study was done to test the efficacy of cisatracurium at a higher dose of 0.3mg/kg when compared to the recommended intubating dose of atracurium of 0.5mg/kg. Materials and methods: This study was done in the Department of Anaesthesia, Alluri SitaRamaraju Academy Of Medical Sciences, Eluru. Study was done for a period from June 2017 to October 2018. Double blind randomized study was conducted after obtaining approval from ethical committee.An informed consent was taken from all patients. Group A (30 patients) received Atracurium 0.5mg/kg IV and Group C (30 patients) received Cisatracurium 0.3mg/kg IV. Results: Duration of action of Cisatracurium (0.3 mg/kg) is significantly high compared to Atracurium (0.5mg/kg) with p<0.001. 83% of patients treated with Cisatracurium had excellent intubating conditions as compared to 47% with Atracurium which was significant. Hemodynamic changes in either of them were clinically insignificant. Signs of histamine release was seen in two patients in Atracurium group whereas none in Cisatracurium group. Conclusion: Cisatracurium at a higher dose of 0.3mg/kg as compared to Atracurium 0.5mg/kg provided more effective and rapid neuromuscular blockade with excellent intubating conditions, longer duration of action, stable hemodynamics and no associated signs of histamine release clinically.