Angiosarcomas comprise only 1% of all sarcomas, of which 60% occur in the skin or soft tissue. Angiosarcoma in the breast is rare, accounting for less than 1% of all malignant mammary lesions. These may be of primary/de novo type in the breast parenchyma or secondary following surgery and radiotherapy. We report a case of post radiation angiosarcoma of the breast, developing 4 years after breast conservation surgery for an invasive duct carcinoma. Following excision of angiosarcomas, local recurrence is common and course aggressive, thus making essential a quick and correct diagnosis and close follow up of such cases.