Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating condition of the central nervous system, and is characterised by multiple areas of white matter involvement.The initial presentation is very similar to multiple sclerosis and thus it needs to be differentiated from it as the treatment for both conditions are different.Thus in this study we present a series of 10 cases which were diagnosed early on MRI.We have also discussed the MRI features and importance of MRI in diagnosing it.