Cardioplegia is integral and important part of myocardial protection. Various cardioplegia solutions and strategies have been devised over last 50 years. Del Nido and St Thomas II solution are common cardiopegias used worldwide. Del nido can be used for 60 to 90 minutes but St Thomas II needs to be repeated every 20 minutes. This study compared both these cardioplegias with repect to inotropic support needed in post cardiopulmonary bypass period. Statistical analysis was done using SPSS version 10. The cross clamp time, cpb time and number of cardioplegia repeated was significantly less in del nido group, however, no significant difference was noted in view of inotropic supports and VIS score.