Infection is defined as invasion of the tissue by a pathogenic mirobes which establishes itself in host tissue, multiplies and results in tissue damage due to release of toxic substances. Among surgical patients, surgical site infections (SSI) are the most common cause of nosocomial infection accounting for up to 38% of all such infections. The commonest and most dangerous complication in vascular surgery is prosthetic graft infection. Up to 2–5% of patients undergoing clean vascular surgery develop SSI. While handling infections, surgeons need to have knowledge of appropriate use of prophylactic and therapeutic antibiotics to mitigate high risk of morbidity and mortality. In this study, we have compared doses of antibiotics in perioperative period in clean vascular surgery, such as single versus triple dose.