– Introduction: Meningitis is a life threatening infection and requires appropriate therapy at the earliest possible moment. Aim: To find out the organisms responsible for causing acute pyogenic meningitis. Method: Detailed history and thorough examination were done in suspected case of meningitis and a tentative diagnosis was made. Routine CSF examination was done and all patient are divided into 4 group pyogenic meningitis, tubercular meningitis, viral meningitis and extracranial infections. Culture of CSF was done to know the etiology. Results: 132 patients met the inclusion criteria with 44 cases of pyogenic meningitis (Group I), 14 cases of tubercular meningitis (Group II), 48 cases of viral meningitis (Group III) and 26 without CNS infections (Group IV). Out of 132 cases only 20 cases were culture positive which was 15.15% of all cases. Streptococcus pneumoniae was the commonest organism cultured.