Objective: To find association between microalbuminuria and stroke severity based on NIHSS and Modified Rankin Scale. Material and Methods: A total of 100 cases and 100 controls that were age/sex matched and admitted during March 2018 to October 2019 were taken into study based on inclusion and exclusion criteria. Urine for microalbumin is tested at the time of admission. Stroke severity was assessed by NIHSS score on admission and prognosis by mRS score at discharge /death. Results: Microalbuminuria is seen in 65%of cases and 8% of controls, (P <0.001). Among100 stroke patients, 100% patients with very severe NIHSS score and 78.26% patients with severe NIHSS score were with microalbuminuria (P <0.001), thus predicting seriousness of stroke in patients with microalbuminuria. Conclusion: We found that MA is an independent risk factor and potential prognostic marker in acute ischemic stroke.