incidence and prevalence. Abnormalities in the structure and function of the thyroid gland and in the metabolism and plasma concentration of Chronic Kidney Disease is a worldwide health problem with an increasing thyroid hormones are common in patients with Chronic Kidney Disease. Patients with CKD having many signs and symptoms suggestive of thyroid dysfunction like sallow complexion, edema, dry skin, cold intolerance, decreased BMR, asthenia and hyporeflexia. So in cases of CKD, it is difficult to exclude thyroid dysfunction on mere clinical background. Total number of 100 patients with Chronic Kidney Disease were selected in this prospective study. 100 patients with Chronic Kidney Disease (CKD) fulfilling the criteria for CKD who were on conservative management were studied, among these 100 patients 70 were male and 30 were female Among the 100 patients in our study 55 of them had low serum T3 levels (55%), 17 patients among the low serum T3 level also had high TSH value of >20 ILIU/m1 with low T4 levels and also symptoms suggestive of hypothyroidism.