Aim: Dengue fever is one of the emerging epidemic occurring in tropical and subtropical regions. As there is no specific antiviral therapy,early diagnosis helps to reduce the morbidity and mortality. Our study is to analyse the utility of hematological parameters along with serological patterns in dengue. Materials and methods: A retrospective study was done for a period of one month in November2019 in the Dept of Pathology, Princess Esra Hospital, Deccan college of Medical Sciences,Hyderabad. Suspected dengue cases were evaluated for serology and hematological investigations. Results: Out of 762 suspected cases,298 cases were confirmed with serology of which 223(75%)were positive for NS1 with/without antibodies.Raised NS1 was associated with hematocrit, normal WBC count, thrombocytopenia & lymphocytosis whereas neutrophilia was linked to antibodies. Conclusion: In resource limited setups,haematological parameters and serology are helpful as early markers of dengue and aid in early diagnosis and management.