BACKGROUND:–Eka kushtha is one among the kshudra kushtha, correlated with psoriasis, a chronic, non infectious skin disease with it’s prevalence ranging from 0.1% to 3%. In modern science using a steroidal therapy having more side effects and chances of recurrence is more. AIM:– To evaluate the efficacy of Virechana karma in the management of ekakushtha with special reference to psoriasis. METHODOLOGY:– Here we present 3 cases of psoriasis with comparing the symptoms before and after virechan karma. Due to hetu sevan (madhur, snigdha guru) increases pischilata and styanata causes decrease in the drava guna, leads to agnimandya and disturbance in the chayapachan process causes formation of Ama (Vishakta dravya) and srotsavrodha causing tiryak gati to dosha leading sthansanshray in twacha (kleda sanchiti) that causes dushti of uttorottar dhatu (rakta, mamsa, lasika) having symptoms kandu, daha, srava, shotha, vedana, vrana. Snehankarma is done before virechana. Snehan causes chedhan bhedhan of doshas at molecular level increasing dravaguna in the molecules leading to doshotkllesha causing increase in the membrane permeability making it tense.The virechan dravya stimulates the membrane in a way that the doshas get transferred from intracellular to extracellular fluid. This process removes the kleda and shodhan of cell. RESULT:–Patient got symptomatic relief. CONCLUSION:– The prevalence of psoriasis increasing day by day. Ayurvedic management is effective in slow down the disease progression and breakdown the pathology.