Cirrhosis can occur as result of various chronic hepatic disease and the incidence of hepatocellular carcinoma arising from cirrhosis is also variable depending on the etiology resulting cirrhosis. Viral hepatitis and alcohol consumption are the most world–wide among the most common causes of HCC.we planned this study to find out the the clinicopathological correlation in chronic liver disease and HCC. This study was done after obtaining the approval from Institutional Human Ethical Committee (IHEC) of Govt. Stanley Medical College, Chennai. 65 liver specimens were taken for this study. Hematoxylin and eosin staining of sections were done. Histopathological examinations of these sections were done. The cases showed an age range from 15 to 73 years. The cases with normal liver histology in the age ranges 15 to 35 years, hepatitis ranges 19 to 51, cirrhosis ranges 15 t0 73 years and the HCC ranges 34–73 years. 45 cases were males and 16 were females.Amongst 8 cases of hepatitis, 4(50%) were males and 4(50%) were females. Amongst 17 cases of cirrhosis, 12(71%) were males and 5(29%) were females. Amongst 30 cases of HCC, 25(83%) were males and 5(17%) were females. chronic alcohol intake history was found in 50% of hepatitis patients, 63% of cirrhosis patients and 83% of HCC patients. In this study the most common risk factor for HCC is chronic alcohol intake followed by viral hepatitis.the significance of the development of hepatocellular carcinoma in the background of chronic hepatocellular injury has been highlighted.