We, here, discuss the history, materials, current indications, recent advances and other important considerations for successful treatment with botulinum toxin. The inclusion criteria includes researches that contain dentofacial applications of botulinum toxin injections as in TMJ disorders, bruxism, oromandibular dystonia, muscle spasm, clenching, oral surgery and implant dentistry, gummy smile, hypertrophy in masseter muscle. Exclusion criteria are the researches that contain applications of botulinum toxin shots other than dentofacial ones.