Introduction: Acute exacerbations of COPD due to either pollution continued smoking, or infections are leading causes of hospital admission and need for mechanical ventilation. AIM This study aims to assess the predictors for the need of Mechanical ventilation in patients with acute exacerbation of COPD with respiratory failure and to propose a new scoring system as a predictor of mechanical ventilation. Results– Out of the 100 patients included in the study, 56 patients required mechanical ventilation. Of them, 41 were managed on NIV, while 15 patients needed invasive ventilation. The predictors for mechanical ventilation were PH, Pco2, heart rate, respiratory rate, age, and total APACHE 2 score. Conclusion Based on the findings of this study, a new scoring system has been proposed to predict the need for mechanical ventilation during the hospital stay. However, more stringent studies are needed to validate the scoring.